Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 10, Pages 1423-1427Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1423
Keywords
benzisoselenazol-3(2II)-one; antiviral agent; antimicrobial agent; organoselenium compound; ebselen
Funding
- [PBZ-Min-015/P05/2004]
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Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Slaphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), ill vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and grain-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (F. coli, P aerughlosa, K. pneumoniae) was substantially, lower. Sonic of tested compounds were active against yeast C albicans and filamentous fungus.A. niger.
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