Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 7, Pages 1002-1004Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1002
Keywords
p-toluenesulfonic acid; polyhydroquinoline; one-pot conversion; multi-component condensation
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A facile and efficient synthetic route to polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of p-toluenesulfonic acid (p-TSA) catalyst in ethanol at ambient temperature through Hantzsch reaction. Simple work-up procedure, environmentally friendly, inexpensive and non-toxic catalyst, shorter reaction times along with excellent product yields are the significant features of this practical method.
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