Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 5, Pages 711-714Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.711
Keywords
Dryopleris crassirhizoina; human immunodeficiency virus (HIV)-1 protease; dryopteric acid A; dryopteric acid B; hopanoic acid
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Two new hopane type triterpenes, named dryopteric acids A (1) and B (2), were isolated from the Rhizome of Dryopteris crassirhizoma (Aspiadaceae) together with sixteen known compounds (3-18). Of isolated compounds, ursolic acid (15), and dryopteric acid A (1) and B (2) showed potent inhibitory activities against HIV-1 protease with IC50 values of 8.9-44.5 mu m. In addition, acetylated compounds 1 and 2 appreciably increased inhibitory activities with their IC50 values of 1.7 and 10.8 mu m, respectively.
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