Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 12, Pages 1729-1731Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1729
Keywords
Daphne feddei; biflavonoid; RAW 264.7 macrophages; nitric oxide
Funding
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- NCET Foundation
- NSFC [30725045]
- National 863 Program [2006AA02Z338]
- China Postdoctoral Science Foundation [20070410711]
- 973 program of China [2007CB507400]
- Shanghai Leading Academic Discipline Project (B906)
- Scientific Foundation of Shanghai China [07DZ19728, 06DZ19717, 06DZ19005]
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Bioassay-directed fractionation led to the isolation of two new biflavonoids and 13 known biflavonoids from a sample of the dried stem barks of Daphne feddei. The structures of compounds I and 2 were elucidated as 2methoxy-daphnodorin C (1) and 2-methoxy-2-epi-daphnodorin C (2) on the basis of detailed spectroscopic analysis and X-ray crystallography. All 15 biflavonoids were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 1, 2, 8, 10, 14 and 15 showed varying degrees of inhibitory activities against the production of NO in tested concentration of 25, 50, 75 and 100 mu g/ml.
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