Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 1, Pages 115-117Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.115
Keywords
Magnolia obovata; Magnoliaceae; 4-methoxymagnaldehyde 13; coumanolignan; cytotoxic activity
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Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds I and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound I showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC50 value of 1.3 mu g/ml.
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