4.3 Article

alpha-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba

Journal

CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 6, Pages 847-850

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.847

Keywords

alpha-glucosidase; immunomodulatory activity; ellagic acid; Terminalia superba

Funding

  1. French Government
  2. Third World Academic of Sciences (TWAS)

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Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together with known 3,3'-di-O-methylellagic acid, ellagic acid and 3,3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside. Compounds (1) and (2) showed significant m-glucosidase inhibition activity and possessed significant immunoinhibitory activities with no cytotoxic effects.

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