Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 373, Issue 1, Pages 16-22Publisher
ACADEMIC PRESS INC
DOI: 10.1006/abbi.1999.1495
Keywords
electron transport complexes; mitochondria; oxidoreductases; aging
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Funding
- NATIONAL INSTITUTE ON AGING [R01AG007657] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG7657, R01AG13564] Funding Source: Medline
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The purpose of the present study was to examine the role of mitochondria in the aging process by determining whether the activities of various electron transport chain oxidoreductases are deleteriously affected during aging and whether the hypothesized age-related alterations in different tissues follow a common pattern. Activities of respiratory complexes I, II, III, and IV were measured in mitochondria isolated from brain, heart, skeletal muscle, Liver, and kidney of young (3.5 months), adult (12-14 months), and old (28-30 months) C57BL/6 mice. Activities of some individual complexes were decreased in old animals, but no common pattern can be discerned among various tissues. In general, activities of the complexes were more adversely affected in tissues such as brain, heart, and skeletal muscle, whose parenchyma is composed of postmitotic cells, than those in the liver and kidney, which are composed of slowly dividing cells. The main feature of age-related potentially dysfunctional alterations in tissues was the development of a shift in activity ratios among different complexes, such that it would tend to hinder the ability of mitochondria to effectively transfer electrons down the respiratory chain and thus adversely affect oxidative phosphorylation and/or autooxidizability of the respiratory components. (C) 2000 Academic Press.
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