Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 30, Issue 6, Pages 970-976Publisher
WILEY
DOI: 10.1111/jgh.12900
Keywords
biliary atresia; inflammation; interleukin-8; liver fibrosis; signaling
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Funding
- National Natural Science Foundation of China [81370472, 81300517]
- Shanghai Rising-Star Program (A type) [15QA1400800]
- Science Foundation of Shanghai [13ZR1451800]
- Shanghai City Health Bureau for Youth Scientific Fund Project [20134y100]
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Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin-8 (IL-8) is an important mediator of inflammation and the immune response in human disease. IL-8 is overexpressed in BA, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL-8 in BA.
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