Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 30, Issue 3, Pages 566-574Publisher
WILEY-BLACKWELL
DOI: 10.1111/jgh.12783
Keywords
chronic hepatitis B; genotype; liver fibrosis; viral load; vitamin D
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Funding
- National Science and Technology Major Project [2012ZX10002003]
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Background and AimThe role of vitamin D playing in patients with chronic hepatitis C has been intensively studied. However, studies on the potential interaction between vitamin D level and chronic hepatitis B are still limited. This study aimed to explore whether any association existed between serum vitamin D level and liver histology or virological parameters in patients with chronic hepatitis B infection in Southern China. Methods25-Hydroxyvitamin D serum levels were determined in a cohort of 242 treatment-naive chronic hepatitis B patients. Histologic assessment was based on Knodell histologic activity index and Ishak fibrosis staging. Predictors of vitamin D insufficiency were identified using multivariate analysis. ResultsMean 25-hydroxyvitamin D value was 33.90ng/mL. The percentage of patients with different concentration of 25-hydroxyvitamin D (30ng/mL, 20-30ng/mL, <20ng/mL) were 59.9%, 31.4%, and 8.7%, respectively. Gender, season, age, and viral genotype were independent predictors of vitamin D insufficiency (<30ng/mL). Patients with genotype B virus infection had a lower mean 25-hydroxyvitamin D level (P=0.023) and higher prevalence of vitamin D insufficiency than those with genotype C (P=0.021), while no association was found between vitamin D status and viral load. In addition, 25-hydroxyvitamin D level did not significantly vary according to activity grade or fibrosis stage. ConclusionsThe prevalence of vitamin D insufficiency is relatively low in our cohort. Patients infected with genotype B had a higher prevalence of vitamin D insufficiency than genotype C. 25-Hydroxyvitamin D serum level is not associated with viral load or fibrosis stage in chronic hepatitis B patients.
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