Preparation and a novel rearrangement reaction of 1,2,3, 4-tetrahydro-9-hydroxy-beta-carboline, and their applications for the total synthesis of (+/-)-coerulescine

Novel 9-hydroxy-beta-carboline derivatives were produced for the first time. A novel rearrangement reaction of 1,2,3,4-tetrahydro-9-hydroxy-beta-carbolines was discovered to give 3,3-disubstituted oxindoles, which was successfully applied to the total synthesis of (+/-)-coerulescine.