Journal
EPILEPSIA
Volume 41, Issue -, Pages S134-S143Publisher
WILEY
DOI: 10.1111/j.1528-1157.2000.tb01572.x
Keywords
epilepsy; status epilepticus; glutamate; NMDA receptors; substance P; tachykinins
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS013515] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS 13515-21] Funding Source: Medline
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We describe a model of self-sustaining status epilepticus (SSSE) induced by stimulation of the perforant path in free-running rats. In this model, seizures can be transiently suppressed by intrahippocampal injection of a blocker of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate synapses but return in the absence of further stimulation when the drug ceases to act. However, seizures are irreversibly abolished by blockers of N-methyl-D-aspartate receptors given locally or systemically. SSSE is enhanced by substance P and its agonists and blocked by its antagonists. SSSE induces novel expression of substance P-like immunoreactivity in hippocampal principal cells. These changes and those in other limbic peptides may contribute to the maintenance of SSSE and to the modulation of hippocampal excitability during epileptic seizures.
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