Journal
NATURE CELL BIOLOGY
Volume 2, Issue 9, Pages 661-665Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35023615
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R29AI030627, R01AI030627] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM039068, R29GM039068] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI30627] Funding Source: Medline
- NIGMS NIH HHS [GM39068] Funding Source: Medline
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The nucleus is known to be compartmentalized into units of function(1), but the processes leading to the spatial organization of chromosomes and nuclear compartments are not yet well defined. Here we report direct quantitative analysis of the global structural perturbations of interphase chromosome and interchromosome domain distribution caused by infection with herpes simplex virus-1 (HSV-1). Our results show that the peripheral displacement of host chromosomes that correlates with expansion of the viral replication compartment (VRC)(2-5) is coupled to a twofold increase in nuclear volume. Live cell dynamic measurements suggest that viral compartment formation is driven by the functional activity of viral components and underscore the significance of spatial regulation of nuclear activities.
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