Journal
MAYO CLINIC PROCEEDINGS
Volume 75, Issue 9, Pages 907-912Publisher
MAYO CLINIC PROCEEDINGS
DOI: 10.4065/75.9.907
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Funding
- NIAMS NIH HHS [AR30582] Funding Source: Medline
- NIA NIH HHS [AG09440] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR030582] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG009440, R55AG009440] Funding Source: NIH RePORTER
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Objective: To evaluate the association between functional gastrointestinal (GI) symptoms and a family history of abdominal pain or bower problems. Subjects and Methods: A valid self-report questionnaire that records GI symptoms and spouse's and first-degree relatives' history of abdominal pain or bowel troubles and includes the psychosomatic symptom check-list (a measure of somatization) was mailed to an age- and sex-stratified random sample of Olmsted County, Minnesota, residents aged 30 to 64 years. A logistic regression model that adjusted for age, sex, and somatic symptom score was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of a positive family history for each functional GI disorder. Results: Six hundred forty-three (72%) of 892 eligible subjects returned the survey, Reporting a first-degree relative with abdominal pain or bowel problems was significantly associated with reporting of irritable bowel syndrome (OR, 2.3; 95% CI, 1.3-3.9) and dyspepsia (OR, 1.8; 95% CI, 1.05-3.0) but not constipation, diarrhea, or gastroesophageal reflux. The reporting of a spouse with abdominal pain or bowel problems was not associated with any of these disorders. Conclusions: A history of abdominal pain or bowel troubles in first-degree relatives was significantly associated with irritable bowel syndrome and dyspepsia. Whether the familial associations represent similar exposures in a shared environment, heightened familiar awareness of GI symptoms (reporting bias), or genetic factors remains to be determined.
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