Journal
GENES & DEVELOPMENT
Volume 14, Issue 17, Pages 2134-2139Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.820400
Keywords
Nkx; spinal cord; motor neurons; neuronal specification; interneurons
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK021344, R01DK021344, P01DK041822] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH001046] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA012462] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01DA12462, R01 DA012462] Funding Source: Medline
- NIDDK NIH HHS [R56 DK021344, R01 DK021344, DK41822] Funding Source: Medline
- NIMH NIH HHS [K02MH01046-01] Funding Source: Medline
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There is growing evidence that sonic hedgehog (Shh) signaling regulates ventral neuronal fate in the vertebrate central nervous system through Nkx-class homeodomain proteins. We have examined the patterns of neurogenesis in mice carrying a targeted mutation in Nkx6.1. These mutants show a dorsal-to-ventral switch in the identity of progenitors and in the fate of postmitotic neurons. At many axial levels there is a complete block in the generation of V2 interneurons and motor neurons and a compensatory ventral expansion in the domain of generation of V1 neurons, demonstrating the essential functions of Nkx6.1 in regional patterning and neuronal fate determination.
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