Journal
MOLECULAR CELL
Volume 6, Issue 3, Pages 605-616Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(00)00059-9
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Funding
- NATIONAL CANCER INSTITUTE [T32CA009213] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM025243] Funding Source: NIH RePORTER
- NCI NIH HHS [T32-CA09213] Funding Source: Medline
- NIGMS NIH HHS [GM25243] Funding Source: Medline
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We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
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