Journal
NATURE NEUROSCIENCE
Volume 3, Issue 9, Pages 919-926Publisher
NATURE AMERICA INC
DOI: 10.1038/78829
Keywords
-
Categories
Funding
- NEI NIH HHS [R01-EY11001] Funding Source: Medline
- NIMH NIH HHS [MH58754] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY011001] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH058754] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Hebbian models of development and learning require both activity-dependent synaptic plasticity and a mechanism that induces competition between different synapses. One form of experimentally observed long-term synaptic plasticity, which we call spike-timing-dependent plasticity (STDP), depends on the relative timing of pre- and postsynaptic action potentials. In modeling studies, we find that this form of synaptic modification can automatically balance synaptic strengths to make postsynaptic firing irregular but more sensitive to presynaptic spike timing. It has been argued that neurons in vivo operate in such a balanced regime. Synapses modifiable by STDP compete for control of the timing of postsynaptic action potentials. Inputs that fire the postsynaptic neuron with short latency or that act in correlated groups are able to compete most successfully and develop strong synapses, while synapses of longer-latency or less-effective inputs are weakened.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available