Journal
GENES & DEVELOPMENT
Volume 14, Issue 17, Pages 2161-2172Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.814700
Keywords
transcription; homeobox gene; development; cell fate; regulation
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM039353] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01GM39353, R01 GM039353] Funding Source: Medline
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The Caenorhabditis elegans caudal homolog, pal-1, is required for neurogenesis in the male tail. We show that expression of pal-1 in the postembryonic neuroblast cell V6 can be initiated by two alternate pathways. One pathway, acting in wild type, requires a regulatory element in the fifth pal-1 intron. The other pathway, independent of this element, is normally repressed by the newly identified gene sop-1, which encodes a homolog of the mammalian Mediator complex protein TRAP230. In sop-1 mutants, pal-1 is activated by a pathway that is stimulated by bar-1/beta-catenin, a component of the Wnt signal transduction pathway. The results support a physiological role of the Mediator complex in conveying regulatory signals to the transcriptional apparatus.
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