Journal
NATURE CELL BIOLOGY
Volume 2, Issue 9, Pages E163-E165Publisher
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35023643
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The molecular pathways that mediate apoptosis are tightly regulated by a series of positive and negative signals, the balance of which determines whether or not cells commit suicide. New data from several laboratories now show that heat-shock proteins (HSPs) can influence this process through direct physical interaction with key components of the apoptotic machinery. These reports marry the survival (or death)-endowing properties of HSPs to the cell-death pathway.
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