Journal
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Volume 12, Issue 3, Pages 365-368Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00042737-200012030-00017
Keywords
amoxycillin-clavulanate potassium; intra-hepatic cholestasis; ursodeoxycholic acid
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This report describes two patients who developed jaundice within two weeks of receiving an amoxycillin - clavulanate potassium combination. Causes of jaundice, other than drug administration, were excluded. The patients' jaundice and clinical symptoms did not respond to stopping the drug. Ursodeoxycholic acid (750 mg/day) led to a prompt and sustained improvement in their hyperbilirubinaemia and symptoms such as pruritus and fatigue. These cases suggest that ursodeoxycholic acid may be an effective treatment for drug-associated cholestasis, Eur J Gastroenterol Hepatol 12:365 - 368 (C) 2000 Lippincott Williams & Wilkins.
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