Journal
PEPTIDES
Volume 21, Issue 3, Pages 393-399Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(00)00156-X
Keywords
neuropeptide Y; neuropeptide Y receptor; Y-5 receptor; [D-Trp(34)]NPY; [D-Trp(32)]NPY; food intake
Funding
- NIGMS NIH HHS [GM47122] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM047122] Funding Source: NIH RePORTER
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The neuropeptide Y (NPY) Y-5 receptor has been proposed to mediate several physiological effects of NPY, including the potent orexigenic activity of the peptide. However, the lack of selective NPY Y-5 receptor ligands limits the characterization of the physiological roles of this receptor. Screening of several analogs of NPY revealed that [D-Trp(34)]NPY is a potent and selective NPY Y, receptor agonist. Unlike the prototype selective NPY Y-5 receptor agonist [D-Trp(32)]NPY, [D-Trp(34)]NPY markedly increases food intake in rats; an effect that is blocked by the selective NPY Y-5 receptor antagonist CGP 71683A. These data demonstrate that [D-Trp(34)]NPY is a useful tool for studies aimed at determining the physiological roles of the NPY Y-5 receptor. (C) 2000 Elsevier Science Inc. All rights reserved.
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