Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 204, Issue 1-2, Pages 17-20Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1007049701572
Keywords
hemoglobin; deferiprone; conformational change
Categories
Ask authors/readers for more resources
The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with the tetrameric allosteric protein hemoglobin from human red blood cells has been investigated spectrofluorometrically and by circular dichroism spectroscopy. The interaction is hydrogenbond like electrostatic in nature, the binding constant being 4.54 x 10(3) M-1 in 0.15 M NaCl. Circular dichroism studies indicate a conformational change of hemoglobin in presence of deferiprone, helicity of hemoglobin being reduced in presence of increasing concentration of the drug L1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available