Journal
NEUROPHARMACOLOGY
Volume 39, Issue 13, Pages 2792-2798Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3908(00)00141-6
Keywords
neurotoxicity; nicotine; amphetamine; MDMA; cocaine; cathinone; habenula; fasciculus retroflexus
Categories
Funding
- NIDA NIH HHS [DA07344] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA007344] Funding Source: NIH RePORTER
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When administered continuously for several days at relatively low plasma levels, a variety of drugs of abuse with strong dopaminergic actions induce degeneration in axons traveling from the lateral habenula through the sheath of fasciculus retroflexus to midbrain monoaminergic nuclei. With some of these drugs, such as cocaine, this is virtually the only degeneration induced in brain. Nicotine given continuously also selectively induces degeneration in fasciculus retroflexus, but in the other half of the tract: the cholinergic axone running from medial habenula in the core of the tract to the interpeduncular nucleus. Fasciculus retroflexus appears to be a weak link in brain for diverse drugs of abuse when administered incessantly for several days. Alterations in this tract would be predicted to be especially important for the genesis of the symptomatology which develops during drug binges, residual effects of such binges, and the processes underlying relapse. (C) 2000 Elsevier Science Ltd. All rights reserved.
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