4.5 Review

Nonviral gene therapy: promises and challenges

Journal

GENE THERAPY
Volume 7, Issue 1, Pages 31-34

Publisher

STOCKTON PRESS
DOI: 10.1038/sj.gt.3301110

Keywords

nonviral vector; gene transfer; gene therapy

Funding

  1. NCI NIH HHS [CA71731, CA59327] Funding Source: Medline
  2. NIDDK NIH HHS [DK44935] Funding Source: Medline
  3. NATIONAL CANCER INSTITUTE [P01CA059327, R01CA071731] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK044935] Funding Source: NIH RePORTER

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The last 10 years have seen substantial progress in the development and application of nonviral vectors in gene therapy. However, many problems remain to be resolved before nonviral gene therapy can become a standard clinical practice. This review highlights the major breakthroughs in this field. The problems and future research directions are also discussed.

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