Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 21, Issue 6, Pages 1093-1097Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0731-7085(99)00182-X
Keywords
histidine; metal-catalyzed oxidation; 2-oxo-histidine; human growth hormone; hydroxyl radical
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Funding
- NATIONAL INSTITUTE ON AGING [P01AG012993] Funding Source: NIH RePORTER
- NIA NIH HHS [P01AG12993] Funding Source: Medline
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The metal-catalyzed oxidation of histidine (His) to 2-oxo-histidine (2-oxo-His) represents an important pathway of protein oxidation in vivo and in vitro. In the pharmaceutical literature this pathway has received less attention. However, this fact may not necessarily represent reality as. in some cases, the analysis of His oxidation in proteins may be compromised by aggregation and precipitation of the target protein. For predicting the susceptibility of His residues in proteins it is important to understand in detail how protein sequence and conformation control the mechanisms of His oxidation to 2-oxo-His, reviewed in this paper. (C) 2000 Elsevier Science B.V. All rights reserved.
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