Journal
PSYCHOPHARMACOLOGY
Volume 147, Issue 4, Pages 436-438Publisher
SPRINGER VERLAG
DOI: 10.1007/s002130050013
Keywords
Delta 9-tetrahydrocannabinol; mouse; reward; place preference; SR 141716A
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Rationale: The rewarding properties of Delta 9-tetrahydrocannabinol (THC) are difficult to demonstrate in rodents using standard procedures. Objective: To evaluate the motivational responses of THC in the place conditioning paradigm in mice after minimizing the dysphoric effects of the first drug exposure and/or the consequences of its pharmacokinetic properties. Methods: Mice were conditioned to THC (1 or 5 mg/kg) using an unbiased procedure with an elevated number of pairings and long conditioning time. Results: A place aversion was observed with 5 mgflcg THC using a standard pl otocol. Similar results were obtained when the CB-1 receptor antagonist SR 131716A (1 mg/kg) was administered immediately after each THC conditioning period. However, mice receiving a priming THC injection and conditioned 24 h later showed a place preference with 1 mg/kg THC and no effect with 5 mg/kg THC, Conclusion: THC produces a clear place preference in mice by using a long period of conditioning and avoiding the possible dysphoric consequences of the first drug exposure.
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