Journal
NATURE CELL BIOLOGY
Volume 2, Issue 1, Pages 13-19Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/71330
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Funding
- NIGMS NIH HHS [R01 GM059618] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059618] Funding Source: NIH RePORTER
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Microtubules are dynamic polymers that move stochastically between periods of growth and shrinkage, a property known as dynamic instability, Here, to investigate the mechanisms regulating microtubule dynamics in Xenopus egg extracts, we have cloned the complementary DNA encoding the microtubule-associated protein XMAP215 and investigated the function of the XMAP215 protein. Immunodepletion of XMAP215 indicated that it is a major microtubule-stabilizing factor in Xenopus egg extracts. During interphase, XMAP215 stabilizes microtubules primarily by opposing the activity of the destabilizing factor XKCM1, a member of the kinesin superfamily. These results indicate that microtubule dynamics in Xenopus egg extracts are regulated by a balance between a stabilizing factor, XMAP215, and a destabilizing factor, XKCM1.
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