Journal
MOLECULAR CELL
Volume 5, Issue 1, Pages 121-131Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(00)80408-6
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM48495, GM31001] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM048495, R01GM031001] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Microsomal cytochrome P450s participate in xenobiotic detoxification, procarcinogen activation, and steroid hormone synthesis. The first structure of a mammalian microsomal P450 suggests that the association of P450s with the endoplasmic reticulum involves a hydrophobic surface of the protein formed by noncontiguous portions of the polypeptide chain. This interaction places the entrance of the putative substrate access channel in or near the membrane and orients the face of the protein proximal to the heme cofactor perpendicular to the plane of the membrane for interaction with the P450 reductase. This structure offers a template for modeling other mammalian P450s and should aid drug discovery and the prediction of drug-drug interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available