Journal
JOURNAL OF ANTIBIOTICS
Volume 53, Issue 9, Pages 954-958Publisher
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.954
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A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast alpha-glucosidase and porcine intestinal alpha-glucosidase with IC50 values of 35 and 50 mu g/ml, respectively. However, it did not show significant inhibitory effects against almond beta-glucosidase, Aspergillus alpha-galactosidase, Escherichia coli beta-galactosidase and jack bean alpha-mannosidase.
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