Journal
ACTA NEUROPATHOLOGICA
Volume 100, Issue 3, Pages 270-274Publisher
SPRINGER VERLAG
DOI: 10.1007/s004010000182
Keywords
ballooned neuron; Golgi apparatus; corticobasal degeneration; Creutzfeldt-Jakob disease
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS036732] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS36732] Funding Source: Medline
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We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.
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