Journal
BRAIN
Volume 123, Issue -, Pages 519-531Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/123.3.519
Keywords
rotarod; Theiler's virus; conduction; inflammation; neuropathology
Categories
Funding
- NIMH NIH HHS [F31 MH012120] Funding Source: Medline
- NINDS NIH HHS [R01 NS032129, R01 NS24180, R01 NS32129, R01 NS024180] Funding Source: Medline
- PHS HHS [1F31ME12120] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH012120] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS024180, R01NS032129] Funding Source: NIH RePORTER
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Recent pathological studies have re-emphasized that axonal injury is present in patients with multiple sclerosis, the most common demyelinating disease of the CNS in humans, However, the temporal profile of demyelination and axonal-loss in multiple sclerosis patients and their independent contributions to clinical and electrophysiological abnormalities are not completely understood. In this study, we used the Theiler's murine encephalomyelitis virus model of progressive CNS inflammatory demyelination to demonstrate mar demyelination in the spinal cord is followed by a loss of medium to large myelinated fibres, By measuring spinal cord areas, motor-evoked potentials, and motor coordination and balance, we determined that axonal loss following,demyelination was associated with electro-physiological abnormalities and correlated strongly with reduced motor coordination and spinal cord atrophy, These findings demonstrate that axonal loss can follow primary, immune-mediated demyelination in the CNS and that the severity of axonal loss correlates almost perfectly with the degree of spinal cord atrophy and neurological deficits.
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