Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 55, Issue 3, Pages B160-B164Publisher
GERONTOLOGICAL SOCIETY AMER
DOI: 10.1093/gerona/55.3.B160
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Funding
- NATIONAL INSTITUTE ON AGING [F32AG005815, R29AG010871, R01AG017143] Funding Source: NIH RePORTER
- NIA NIH HHS [AG10871, F32 AG005815, F32 AG005815-01, R01 AG017143-03, R01 AG017143-04] Funding Source: Medline
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA, protein, and enzyme activity levels in hindlimb muscles of adult and senescent Fischer 344 x Brown Norway rats were investigated. Soleus muscles From adult and senescent rats had similar levels of GAPDH. In contrast, muscles containing a large proportion of glycolytic fibers had lower GAPDH levels in senescent rats relative to these muscles in adult rats; this was observed at both the mRNA and protein levels. These data indicate that skeletal muscle glycolytic capacity of fast muscles is diminished with age and that it may he caused by changes at the level of transcription. Also, because GAPDH mRNA levels change with age in several rat muscles, GAPDH mRNA is not always a proper internal control for mRNA analyses of aging skeletal muscle.
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