Journal
MICROBES AND INFECTION
Volume 2, Issue 3, Pages 251-255Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(00)00303-8
Keywords
Toll; interleukin-1; lipopolysaccharide; receptor; inflammation
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Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria. Differential expression and regulation as well as distinct though overlapping ligand recognition patterns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robust. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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