Journal
DIABETIC MEDICINE
Volume 17, Issue 3, Pages 171-180Publisher
WILEY
DOI: 10.1046/j.1464-5491.2000.00259.x
Keywords
ascorbic acid; diabetes mellitus; glutathione; lipoate; oxidative; stress; reactive oxygen species; vitamin E
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Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2 diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins. Mechanisms are considered whereby hyperglycaemia can increase oxidative stress, and change the redox potential of glutathione and whereby reactive oxygen species can cause hyperglycaemia. It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.
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