Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 26, Issue 12, Pages 1303-1307Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-100102313
Keywords
controlled release; lobenzarit disodium; matrix tablets; optimization
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The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit(R) RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t(90%) was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 mul, and CE = 0).
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