Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 78, Issue 3, Pages 121-129Publisher
SPRINGER VERLAG
DOI: 10.1007/s001090000094
Keywords
cyclo-oxygenase; nonsteroidal anti-inflammatory drugs; inflammation; peroxisome proliferator-activated receptor; cyclopentenone prostaglandins; stress proteins
Ask authors/readers for more resources
Cyclo-oxygenase (COX) is responsible for the synthesis of bioactive prostanoids, the inhibition of which serves as the basis for the mode of action of clinically used nonsteroidal anti-inflammatory drugs. While there were suggestions as early as the 1970s that an inducible isoform of COX exists, it was only in the early 1990s that COX 2 was identified, cloned and sequenced. Not surprisingly, this new isoform was expressed at sites of inflammation and reported to contribute to the inflammatory response. Recently, however, evidence is emerging to suggest that COX 2 also has anti-inflammatory properties. In this review, the two faces of COX 2 are examined, with emphasis on its role in regulating inflammatory resolution, including possible mechanisms of action.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available