Journal
JAPANESE JOURNAL OF PHARMACOLOGY
Volume 82, Issue 1, Pages 15-20Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jjp.82.15
Keywords
Ca2+ wave; Ca2+ oscillation; Inositol 1,4,5-trisphosphate receptor; phospholipase C
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Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ signalling regulates many important cell functions, and the spatio-temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility. The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns. I also discuss the spatio-temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration. These findings highlight the potential importance of the spatio-temporal information of any signalling molecule.
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