Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time

Objectives: To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP), Methods: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to less than or equal to 15 s in patients with acquired coagulation deficits, Results: 45 patients (22 SDP vs, 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46], percentage of patients who corrected their PT to less than or equal to 15 s (32% for SDP vs, 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). Conclusion: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits. Copyright (C) 2000 S. Karger AG, Basel.