Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 26, Issue 3, Pages 343-347Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-100100363
Keywords
diclofenac; nanocapsules; spray-dried nanocapsules
Categories
Ask authors/readers for more resources
Recently, much interest has been generated by colloidal drug delivery systems such as nanocapsules because of the possibilities for controlled release, increased drug efficacy, and reduced toxicity after parenteral administration. Nanocapsules of poly-epsilon-caprolactone and Eudragit S90(R) were prepared. However, these systems present physicochemical instability. To dry these nanocapsule suspensions with the view of obtaining a solid form, the spray-drying process was used. Spray-dried powders of nanocapsules of poly-epsilon-caprolactone and Eudragit S90(R) were prepared by atomization in a Buchi 190 Mini-spray dryer using colloidal silicon dioxide as a technological carrier. The morphological analysis of the surface at the powders showed that nanocapsules remain intact, and no change in particle size was detected after the spray-drying process. These results suggest that this method can be an interesting alternative to dry nanocapsule suspensions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available