Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 26, Issue 9, Pages 985-988Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-100101326
Keywords
acetaminophen; drying; fluid bed; granulation; ibuprofen; near infrared; NIR
Categories
Ask authors/readers for more resources
A fast-drying method to accelerate the fluid bed drying process is presented. It relies on concepts of heat and mass transfer with real-time near-infrared (NIR) monitoring of moisture. Triplicate trials show that fast drying can reduce granulation drying time by half over single-temperature cycles. The product is equivalent in every way tested to material made using a conventional cycle even though the inlet temperature throughout the constant-rate stage was higher than the melting point of the compound Tablets made from the fast-dried granulation exhibit equivalent physical characteristics to tablets made from granulations dried at a single, lower temperature.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available