Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 26, Issue 7, Pages 791-795Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-100101301
Keywords
alginates; beads; Compritol 888; diclofenac sodium
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Sustained-release polymer beads containing diclofenac sodium (DNa) dispersed in Compritol 888 and encapsulated in calcium alginate shell were prepared utilizing 2(3) factorial design. The effect of sodium alginate concentration, drug:Compritol 888 weight ratio and CaCl2 concentration on drug content (%), time for 50% and 80% of the drug to be released, and mean dissolution time (MDT) were evaluated with analysis of variance (ANOVA). An increase in the level of all these factors caused retardation in the release,and t(50%), t(80%), and MDT were increased. The drug release was dependent on the pH of the release media. A formula that gives a release comparable to commercial products was prepared.
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