Journal
JOURNAL OF ANTIBIOTICS
Volume 53, Issue 1, Pages 50-57Publisher
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.50
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The mutant of Penicillium sp. FO-4259, an arisugacins A and B producing strain, was found to produce a series of metabolites, designated arisugacins C, D, E, E G and H, which were structurally related to arisugacins A and B. These compounds were isolated from the culture broth and the physico-chemical and biological properties were examined. The IC50 values of arisugacins C and D against acetylcholinesterase (AChE) were 2.5 mu M and 3.5 mu M, respectively. However arisugacins El F, G and H did not inhibit AChE at I OD mu M. Though they showed only weak or no activity against AChE compared with arisugacins A and B, they may be useful for the study of the structure-activity relationship.
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