Journal
NEUROPSYCHOLOGIA
Volume 38, Issue 5, Pages 596-612Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3932(99)00103-7
Keywords
visual discrimination; concurrent; dopamine; reward; cortical
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Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.
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