Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 63, Issue 2, Pages 147-152Publisher
SPRINGER
DOI: 10.1023/A:1006495824158
Keywords
Indole-3-carbinol; breast cancer; invasion; migration; PTEN; E-cadherin
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Funding
- NCI NIH HHS [R01-CA82599] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA082599] Funding Source: NIH RePORTER
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Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
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