Journal
IMMUNOLOGY TODAY
Volume 21, Issue 9, Pages 455-464Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0167-5699(00)01692-3
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Funding
- NCI NIH HHS [CA67108] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA067108] Funding Source: NIH RePORTER
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Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.
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