Journal
MOLECULAR GENETICS AND METABOLISM
Volume 71, Issue 1-2, Pages 315-320Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/mgme.2000.3044
Keywords
IGF-I receptor; WT1; p53; BRCA1; tumor suppressor; transcription; gene expression; oncogenes
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The insulin-like growth factor-I receptor (IGF-I-R) has a central role in normal cellular proliferation as well as in transformation processes, Transcription of the IGF-I receptor gene is controlled by a number of tumor suppressors, including WT1, p53, and BRCA1, It has been demonstrated that, in their wild-type form, these transcription factors can suppress the activity of the IGF-I-R promoter, with ensuing reduction in the levels of cell-surface IGF binding. On the other hand, a number of oncogenes, including mutant p53 and c-myb, and the fusion protein EWS-WT1 significantly stimulate promoter activity. Interactions between stimulatory and inhibitory transcription factors may determine the level of expression of the IGF-I-R gene and, consequently, the proliferative status of the cell. (C) 2000 Academic Press.
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