Journal
PEDIATRIC NEUROSURGERY
Volume 32, Issue 3, Pages 132-136Publisher
KARGER
DOI: 10.1159/000028917
Keywords
low-grade astrocytoma; midline tumor; childhood; spontaneous regression; neurofibromatosis
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An 8-year-old boy with neurofibromatosis type 1 (NF1) and a biopsy-proven juvenile pilocytic astrocytoma of the hypothalamic/chiasmatic region was followed with serial MRIs over 4 years. Spontaneous tu mor regression was followed by progression and biopsy; 6 months later, the tumor regressed again. This bimodal regression is rare, but highlights the variable natural history of low-grade gliomas in children with NF1 and the difficulty in evaluating response of such tumors to therapy. Copyright (C) 2000 S.Karger AG, Basel.
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