Journal
EXPERIMENTAL EYE RESEARCH
Volume 70, Issue 3, Pages 307-313Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/exer.1999.0797
Keywords
aqueous humor outflow facility; latrunculin B; monkey eye; trabecular meshwork
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Funding
- NATIONAL EYE INSTITUTE [R01EY002698] Funding Source: NIH RePORTER
- NEI NIH HHS [EY02698] Funding Source: Medline
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Latrunculin-B (LAT-B), a macrolide derived from the marine sponge Latrunculia magnifica, sequesters monomeric G-actin, leading to the disassembly of actin filaments in cultured cells. In this study, we determined the effect of LAT-B on outflow facility in living monkeys. Total outflow facility was measured by 2-level constant pressure perfusion of the anterior chamber (AC) before and immediately after AC exchange infusion or 2 hr after topical application of LAT-B or vehicle. Both AC exchange infusion and topical application of LAT-B dose- and time-dependently increased outflow facility by two- to four-fold. Those findings suggest that pharmacological disorganization of the actin cytoskeleton in the trabecular meshwork. by specific actin inhibitors such as LAT-B may be a useful anti-glaucoma strategy. (C) 2000 Academic Press.
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