Journal
IMMUNOLOGY TODAY
Volume 21, Issue 3, Pages 110-113Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0167-5699(99)01573-X
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Funding
- NIAID NIH HHS [AI40098] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI040098, R01AI040098] Funding Source: NIH RePORTER
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Tumor necrosis factor (TNF)-mediated activities are potentially numerous, although in TNF-deficient ((-/-)) mice, altered spatial orientation of leukocytes within tissues is the predominant phenotype. Here, we propose that TNF plays a fundamental role in the control of leukocyte movement by virtue of a pivotal role in regulation of chemokine expression.
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