Journal
AUSTRALIAN JOURNAL OF CHEMISTRY
Volume 53, Issue 2, Pages 143-147Publisher
C S I R O PUBLISHING
DOI: 10.1071/CH99166
Keywords
antitumour; cytotoxic; synthesis; carboxamides; quinoline
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The acid precursors of the title compounds were prepared from methyl 2-amino-3-formylbenzoate (3), by Friedlander synthesis with o-methoxy- and o-nitro-phenylacetic acids, phenylpyruvic acid and benzo[b]thiophen-2-one, respectively. Except for the last example, cyclization of an initial 3-arylquinoline derivative was then required to give the tetracycle. Growth inhibition properties of the carboxamides in a series of cancer cell lines were measured for comparison with previous data for an isomeric series. In all cases, the present set were found to be less active.
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