Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 19, Issue 1-2, Pages 371-377Publisher
MARCEL DEKKER INC
DOI: 10.1080/15257770008033015
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Low levels of the CTP synthase inhibitor 3-deazauridine (3-DU) strongly potentiated the anti-HLV-1 activity of the 5'-triphosphates of the cytidine-based analogues [-]2'-deoxy-3'-thiacytidine (3TC; lamivudine) and 2',3'-dideoxycytidine (ddC). The potentiation was associated with a 3-DU-induced decrease in dCTP pool size; no changes were seen in cellular pool sizes of dATP, dGTP or dTTP.
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